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Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence BJMBR
da Luz,P.L.; Coimbra,S.; Favarato,D.; Albuquerque,C.; Mochiduky,R.I.; Rochitte,C.E.; Hojaij,E.; Gonsalves,C.R.L.; Laurindo,F.R..
Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Atherosclerosis; Red wine; Lifestyle; Computer tomography angiography; Coronary calcium; Carotid plaques.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000800697
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Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model BJMBR
Barbeiro,H.V.; Barbeiro,D.F.; Debbas,V.; Souza,H.P.; Laurindo,F.R.; Velasco,I.T.; Soriano,F.G..
Sepsis involves a systemic inflammatory response of multiple endogenous mediators, resulting in many of the injurious and sometimes fatal physiological symptoms of the disease. This systemic activation leads to a compromised vascular response and endothelial dysfunction. Purine nucleotides interact with purinoceptors and initiate a variety of physiological processes that play an important role in maintaining cardiovascular function. The purpose of the present study was to investigate the effects of ATP on vascular function in a lipopolysaccharide (LPS) model of sepsis. LPS induced a significant increase in aortic superoxide production 16 h after injection. Addition of ATP to the organ bath incubation solution reduced superoxide production by the aortas of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ATP; Endotoxin; Endothelium; Superoxide; Nitric oxide.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100009
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Red wine consumption, coronary calcification, and long-term clinical evolution BJMBR
da Luz,P.L.; Favarato,D.; Moriguchi,E.H.; de Carli,W.; Bruscato,N.; Mochiduky,R.I.; Schwartzman,P.; Rochitte,C.E.; Laurindo,F.R..
Coronary artery calcification (CAC) is associated with atherosclerotic complications. However, elevated CAC may not always imply a worse prognosis. Herein, we report the clinical evolution of long-term red wine (RW) drinkers in relation to CAC. We followed 200 healthy male habitual RW drinkers and compared them to 154 abstainers for a period of 5.5 years. The initial evaluation included coronary computed tomography angiography (CTA), clinical, demographics, and laboratory data. CAC was quantified by the Agatston score. The follow-up process was conducted by telephone calls and/or hospital record review. The composite end-point of total death, acute myocardial infarction (AMI), or coronary revascularization (or major adverse cardiac event - MACE) was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary calcification; Red wine; Clinical outcome; Prevention; Plaque.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200613
Registros recuperados: 3
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